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KMID : 0880220220600030290
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Journal of Microbiology
2022 Volume.60 No. 3 p.290 ~ p.299
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SARS-CoV-2-mediated evasion strategies for antiviral interferon pathways
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Oh Soo-Jin
Shin Ok-Sarah
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Abstract
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With global expansion of the COVID-19 pandemic and the emergence of new variants, extensive efforts have been made to develop highly effective antiviral drugs and vaccines against SARS-CoV-2. The interactions of coronaviruses with host antiviral interferon pathways ultimately determine successful viral replication and SARS-CoV-2-induced pathogenesis. Innate immune receptors play an essential role in host defense against SARS-CoV-2 via the induction of IFN production and signaling. Here, we summarize the recent advances in innate immune sensing mechanisms of SARS-CoV-2 and various strategies by which SARS-CoV-2 antagonizes antiviral innate immune signaling pathways, with a particular focus on mechanisms utilized by multiple SARS-CoV-2 proteins to evade interferon induction and signaling in host cell. Understanding the underlying immune evasion mechanisms of SARS-CoV-2 is essential for the improvement of vaccines and therapeutic strategies.
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KEYWORD
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SARS-CoV-2, COVID-19, interferon, immunity
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